贝那普利对良性前列腺增生合并原发性高血压患者血管内皮功能影响的临床研究

Effects of Benazepril on endothelial function in patients with benign prostatic hyperplasia complicated with essential hypertension.

目的研究贝那普利对良性前列腺增生（BPH）合并原发性高血压患者血管内皮功能的影响，探讨贝那普利在降压治疗同时缓解BPH症状的作用机制。方法53例BPH合并原发性高血压患者，应用贝那普利10mg，1次／d口服，治疗8周。检测治疗前、后的血浆内皮素-1（ET-1）、一氧化氮（NO）、血管性假血友病因子（vWF）水平；应用二维超声测量治疗前、后的肱动脉血流依赖性舒张功能（FMO），观察血管内皮功能的变化；同时检测正常对照组（39例健康男性）ET-1、NO、vWF及FMD水平。观察治疗前后患者BPH的主观及客观症状变化情况。结果治疗前、后ET-1、NO、vWF和FMD水平比较差异均有统计学意义（均P〈0．05），治疗后各指标水平趋于正常对照组水平；治疗后患者BPH的主观及客观症状均有一定程度的缓解。结论改善血管内皮功能可能是贝那普利在降压治疗同时缓解BPH症状的作用机制之一。

Objective To observe the effects of Benazepril on endothelial function in patients with benign prostatic hyperplasia （BPH） complicated with essential hypertension （ EH ） and to explore the mechanism of benazepril in relieving BPH symptoms. Methods Fifty three subjects received Benazepfil 10mg/d for 8 weeks. Endothelin- 1 （ ET-1 ） ,nitric oxide （NO） ,yon wiUber factor（vWF） were assayed by biochemical assay,brachial artery flow-mediated dilatation （FMD） function was measured by high-resolution vascular ultrasonography. 39 cases of normal male were taken as control group. The objective and subjective symptoms were compared in BPH patients before and after treatment. Results ET-1 ,NO and vWF, and FMD were signiilcantly different （P 〈 0.05 ） before and after treatment, and the parameters after treatment tended to be normal. The symptoms of BPH patients were relieved to some extent. Conclusion Benazepril improves BPH syndromes in patients with BPH complicated with EH by influencing the endothelial function.