高敏C反应蛋白在新生儿细菌感染性疾病诊断中的意义

The significance of high sensitive C reactive protein for the early diagnosis of neonatal bacterial infection

目的探讨高敏C反应蛋白(hsCRP)在新生儿细菌感染性疾病诊断中的意义。方法对2004年11月至2005年10月我院收治的100例疑似细菌感染住院新生儿进行前瞻性研究,分析hsCRP、传统CRP和外周血常规3种检测标准对新生儿细菌感染性疾病诊断的敏感性、特异性等。结果本组细菌感染38例,非细菌感染62例。hsCRP≤2.25mg/L者72例,2.26￣7.99mg/L者11例,传统CRP≥8mg/L者17例;血常规阳性者22例,阴性者78例。hsCRP诊断细菌感染的敏感性和约登指数高于另外两种检测标准。结论hsCRP是诊断新生儿细菌感染的适宜指标。

Objective To evaluate the significance of the high sensitive C reactive protein test for the early diagnosis of neonatal bacterial infection. Methods 100 neonatal cases with suspected bacterial infection who were admitted to our neonatal ward during 2004 to 2005 were enrolled to perform a prospective study. The hsCRP, CRP and blood routine test of all the cases were conducted and analyzed with their clinical characteristics. Results In the 100 cases, there were 38 cases with bacterial infection （n=38） and the other 62 neonates without bacterial infection （n=62）. There were 72 cases with hsCRP level below 2.25mg/L （hsCRP ≤ 2.25mg/L） and 11 cases in the range of 2.26mg/L to 7.99mg/L. The cap level of 17 cases was above 8mg/L （CRP≥ 8mg/L）. The sensitivity and the Youden index of hsCRP for the diagnosis of focal bacterial ingection were higher than others. Conclusions HsCRP test is feasible for the diagnosis of neonatal bacterial infection.