益可颗粒对正常及糖尿病模型小鼠的降糖作用研究

Effect of Yike Granules on Blood Sugar in Normal and Experimental Diabetic Mice

目的:观察益可颗粒对正常和实验性高血糖小鼠血糖水平的影响。方法:正常小鼠连续灌胃给药15d后,利用血糖试纸检测不同剂量益可颗粒对正常小鼠血糖影响;腹腔注射四氧嘧啶制备糖尿病小鼠模型,实验随机分为7组,每组10只小鼠,即正常对照组、模型对照组,阳性对照组、联合用药组、益可颗粒高剂量组(6.0g/kg)、益可颗粒中剂量组(3.0g/kg)及益可颗粒低剂量组(1.0g/kg),连续灌胃30d后,以血搪试纸测定小鼠空腹血糖。结果:三个剂量的益可颗粒连续灌胃给药15天,均不影响正常小鼠的血糖和体重;6.0g/kg益可颗粒组连续灌胃给药30d,可明显降低四氧嘧啶诱发的高血糖小鼠血搪。结论:益可颗粒不降低正常小鼠血糖,可降低实验性糖尿病小鼠的血糖。

Objective：To observe the effects of Yike granules on blood sugar in normal and experimental diabetic mice.Methods：The blood glucose was determined after the normal mice given drugs for 2 weeks.The diabetic mices weremodeled by giving alloxan intraperitoneally,seven groups in the experiment with random allocation were normal control group,diabetic model group.positive control group,combination group,high dose of Yike granules group（6.0g/kg）,middle dose of Yike granules group（3.0g/kg）,low dose of Yike granules group（1.0g/kg）.The blood glucose was determined.Results：Yike granules had no effect on the weight of normal and diabetic mice,the high dose of Yike granules could obviously decreased the blood sugar level（P〈0.05）.Conclusion：Yike granules could effectively decrease blood glucose in the diabetic mice but had no effect on the normal mice.