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血管内皮生长因子与小儿川崎病血管损伤的关系 被引量：1

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摘要 目的探讨血管内皮生长因子(VEGF)在小儿川崎病血管损伤中的作用机制。方法应用酶联免疫吸附实验(ELISA)检测52例川崎病(KD)患儿急性期、缓解期及28例健康对照组儿童血浆VEGF含量,并将KD患儿分为有冠脉损伤(CAL)组与无冠脉损伤(NCAL)组。结果KD患儿组急性期和缓解期的VEGF水平均显著高于健康对照组[分别为(231.26±75.31)pg/ml,(127.67±63.17)pg/ml比(43.94±19.58)pg/ml,P<0.01];NCAL组急性期VEGF水平明显高于CAL组[(269.99±69.33)pg/ml比(184.10±52.48)pg/ml,P<0.01],缓解期NCAL组血浆VEGF含量下降值显著大于CAL组;KD患儿组急性期血浆VEGF水平与血清白蛋白呈显著负相关(r=-0.604,P<0.01)。结论VEGF参与了川崎病血管损伤的病理生理过程,持续不降的VEGF可能与KD发生了冠脉损伤有关。
作者 韦茹 张丽 曾华松 姚翠婵 熊小燕 唐娟 虢艳 王蓓
机构地区 广东省广州市儿童医院过敏免疫风湿科 广东省广州市儿童医院心血管科 广东省广州市儿童医院危重病实验室
出处 《广东医学》 CAS CSCD 北大核心 2008年第1期66-67,共2页 Guangdong Medical Journal
基金 广东省社会发展领域科技计划项目(编号:63097) 广州市卫生局重点项目(编号:2005-Zdi-08) 广州市卫生局一般引导项目(编号:2005-YB-064)
关键词 黏膜皮肤淋巴结综合征 血管内皮生长因子 冠状动脉损伤 儿童
分类号 R735.2 [医药卫生—肿瘤]
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参考文献10

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共引文献29

同被引文献7

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二级引证文献1

广东医学
2008年 第1期

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