支气管动脉灌注治疗老年肺癌临床疗效观察

Evaluation of clinical effect of bronchial arterrial infusing in old patients with lung cancer

目的对比分析中晚期老年肺癌经支气管动脉灌注与全身化疗的疗效。方法88例确诊的中晚期老年肺癌患者，随机分为静脉全身化疗（对照组）和经导管支气管动脉内灌注化疗药物（观察组）。间隔3～4周治疗1次，3次治疗后评价临床疗效、毒副反应，随访生存时间等，用统计学方法分析两组治疗差别。结果治疗后对照组、观察组的有效率分别为30．5％和56．5％，经χ^2分析两组间有效率差异有显著性，白细胞下降、静脉炎发生率观察组明显减少，生存时间明显延长。结论经导管支气管动脉灌注化疗疗法和全身静脉化疗相比能更有效地控制原发病灶，对老年晚期肺癌患者是一个有效的治疗方法。

Objective To analyze the clinical effect of bronchial arterial infusing and systemic vein chemotherapy on moderate and advanced lung cancer in old patients. Methods 88 cases with advanced lung cancer were randomly divided into a control group treated with systemic vein chemotherapy and a treatment group treated with transcatheter bronchial arterial infusing （BAI）. An interval of treatment period of 3 - 4 weeks was conducted one time. The clinical effect and toxicities responses ware valuated after 3 times treatment, using statistical method for group comparisons. Results The total effective rate was 30.5% in the control group and 56. 5% in the treatment group： P 〈 0. 05. Leucocyte decreased, phlebitis rate significant reduced, which prolonged the length of survival. Conclusion The primary focus can be controlled by BAI compared with systemic vein chemotherapy, BAI is hopeful for enhancement of therapeutic effect for old patients with advanced lung cancer.