红霉素治疗持续漏气的自发性气胸疗效观察

Effect of erythromycin on persistent air-leak spontaneous pneumothorax

目的观察红霉素胸膜腔内注入治疗持续漏气的自发性气胸的作用及安全性。方法选择肋间闭式引流7～10d，继以持续负压吸引72h以上，仍持续漏气的自发性气胸61例，胸膜腔内注入红霉素1g＋50％葡萄糖60ml，并与32例单用50％葡萄糖60ml者作为对照。结果红霉素组治愈率为（49／61）80．3％，明显高于对照组（11／31）35．5％。治疗组不良反应中胸痛发生率仅为19．2％，发热发生率为20．1％。结论红霉素胸膜腔内注入是治疗持续漏气的自发性气胸的有效方法。

Objective To investigate the value of erythromycin plus 50% glucose in the treatment of refractory （ persistent air-leak beyond 10 - 14 d） spontaneous pneumothorax. Methods 92 patients with refractory pneumothorax were randomly divided into two groups and treated with a dose of lg erythromycin plus 50% glucose 60 ml （erythromycin group） or 50% glucose only （ glucose group） that was injected into the pleural cavity respectively. Results After injection in the erythromycin group, 80. 3% （49/61） of air-leaks ceased, in the glucose group, 35.5 % （ 11/31 ） of air-leaks resolved. The therapeutic effect in the erythromycin group were significantly higher than that in the glucose group （ P 〈0. 05）. The major side effect was chest pain （ 19. 2% ） and fever （ 20. 1% ）. Conclusion This study demonstrates that erythromycin plus 50% glucose is safe and effective for treatment of patients with persistent air-leak spontaneous pneumothorax.