摘要
目的:对比观察药物支架(DES)与普通支架(BMS)对PCI患者高敏C反应蛋白水平(Hs-CRP)的影响,探讨经皮冠状动脉介入治疗(PCI)术后再狭窄的发生机制。方法:置入了单个支架的冠心病稳定性心绞痛患者83例入选本研究,DES组43例,BMS组40例,另选同期住院行冠脉造影检查显示冠状动脉不同程度的狭窄,而未行PCI的冠心病患者35例做对照组,分别于术前和术后48、72 h和2周测定血清Hs-CRP。结果:术前三组患者临床特征及冠脉造影显示的病变特征相似,具有可比性,术前及术后2周血清Hs-CRP水平组间无显著差别,术后48、72 hPCI患者较对照组Hs-CRP水平显著升高[48 h(13.42±14.70)mg/L比(5.89±4.93)mg/L,P<0.01;72 h(16.67±19.81)mg/L比(5.38±3.94)mg/L,P<0.01],但DES组与BMS组比较升高幅度小[48 h(6.26±4.36)mg/L比(21.02±15.46)mg/L,P<0.01;72 h(4.83±3.50)mg/L比(15.03±9.79)mg/L,P<0.01)。结论:PCI可显著升高Hs-CRP水平,但DES与BMS相比,可明显降低Hs-CRP水平,表明DES可明显抑制PCI术后诱发的急性炎症反应,继而抑制血管平滑肌细胞的增殖和迁移,可能是其预防PCI术后再狭窄的机制之一。
Objective ：To compare the effect of DES and BMS stenting on the levels of serum High-sensitive C reactive protein （Hs-CRP） and to investigate the mechanism of restenosis after coronary stenting. Methods,, 83 patients with stable angina underwent with single stent, 35 patients coronary artery stenosis exceeding 70~ did not recveive PCI for various kinds of reason, all patients were enrolled in this study. Serum Hs-CRP levels were determined before inter- vention and at 48 hours, 72 hours, as well as 2 weeks after coronary stenting. Result..There was no difference in clinical and angiographic baseline characteristics in patients. After PCI or CAG serum Hs-CRP levels were significantly higher in the stent implantation group than in the CAG group at 48 hoursE（13. 42±14. 70） mg/L vs （5.89±4.93） mg/L,P〈 0.01land 72 hoursE（16.67±19. 81） mg/L vs （5.38±3.94） mg/L,P〈0.01];moreover, after stent implantation Hs- CRP levels were significantly lower in the DES group than in the BMS group at 48 hoursE（6. 26±4. 36） mg/L vs （21.02 ±15.46） mg/L,P〈0. 01] and 72 hours [（4. 83±3. 50） mg/L vs （15.03±9.79） mg/L,P〈0.01]. Conclusions：DESs show significantly lower serum Hs-CRP levels after coronary stenting compared with BMSs. This may reflect the potent effects of DESs on acute inflammatory reactions induced by coronary intervention.
出处
《中国误诊学杂志》
CAS
2008年第1期1-3,共3页
Chinese Journal of Misdiagnostics
