纳洛酮促进急性有机磷农药中毒呼吸衰竭恢复的临床观察

Naloxone and acute organophosphorus pesticide poisoning-related respiratory failure

为探讨纳洛酮对急性有机磷农药中毒呼吸衰竭恢复的影响。将1997年6月至2000年5月在我院住院治疗的急性有机磷农药中毒呼吸衰竭患者106例作为对照组；2000年6月至2002年9月我院收治的同类患者83例作为研究组，在进行相同治疗的同时静脉注射纳洛酮，观察两组患者机械通气的时间。两组机械通气时间，研究组（235±89）h，对照组（342±123）h（t=6．92，P〈0．01）。说明纳洛酮可以明显促进急性有机磷农药中毒呼吸衰竭患者恢复自主呼吸。

This study was to examine the influence of Naloxone on respiratory failure among patients with acute organophosphorus pesticide poisoning （AOPP）. From June 1997 to May 2000, 106 AOPP-related respiratory failure patients were assigned to the control group. During June 2000 to September 2002, 83 matched patients were assigned to the treatment group and obtained intravenous Naloxone injection. Duration of mechanical ventilation was recorded. In comparison to the treatment group, the control group showed prolonged mechanical ventilation [（342±123） h vs （235±89） h; t = 6.92, P 〈 0.01 ], demonstrating that intravenous Naloxone injection may promote the respiratory failure patients. of independence-breathing in AOPP-related respiratory failure patients.