血清妊娠标志物测定在异位妊娠诊断中的价值

Diagnostic value of serum pregnant markers for ectopic pregnancy

目的:评价妊娠标志物孕酮、妊娠相关血浆蛋白A及血管内皮生长因子单项检测及联合检测在异位妊娠诊断上的价值。方法:测定34例异位妊娠患者和34例正常妊娠者的血清孕酮、妊娠相关血浆蛋白A及血管内皮生长因子水平,通过计算受试者工作特征曲线下面积评价上述监测指标的诊断价值。结果:异位妊娠组与正常妊娠组的血清孕酮、妊娠相关血浆蛋白A及血管内皮生长因子水平有显著差异;血清孕酮、妊娠相关血浆蛋白A及血管内皮生长因子单个检测及联合检测的受试者工作特征曲线下面积分别为0.980,0.611,0.637和0.969。结论:血清孕酮、妊娠相关血浆蛋白A及血管内皮生长因子检测有助于异位妊娠的早期诊断,但此三联检测并不优于单项血清孕酮指标。

Objective To explore the clinical diagnostic value of single and combined detection of serum pregnant markers（serum progestone,pregnancy associated plasma protein A and vascular endothelial growth factor） for ectopic pregnancy.Methods Serum progestone,pregnancy associated plasma protein A and vascular endothelial growth factor were measured in 34 patients with ectopic pregnancy and 34 healthy pregnant women.Receiver operating characteristic curves of all indexes were drawn and the areas under the receiver operating characteristic curves（AUC） were calculated to evaluate diagnostic value.Results Levels of serum progestone,pregnancy associated plasma protein A and vascular endothelial growth factor were significantly different between ectopic pregnant patients and normal pregnant women.AUC of serum progestone,pregnancy associated plasma protein A and vascular endothelial growth factor and their combination were 0.980,0.611,0.637 and 0.969 respectively.Conclusion Detection of serum progestone,pregnancy associated plasma protein A and vascular endothelial growth factor are helpful for the early diagnosis of ectopic pregnancy.But combination of them has no advantage compared to single determination of serum progestone.