不同剂量阿托伐他汀对高血压病相关指标影响的研究

Effects of different doses of atorvastatin on serum lipids,endothelial function and clinical events in hyperlipidemic patients

目的探讨不同剂量阿托伐他汀治疗后对高血压病患者血脂、血管内皮功能及脑钠肽水平的影响。方法将确诊的166例高血压合并高脂血症病人随机分成3组,分别接受阿托伐他汀10 mg/d(56例,A组)、20 mg/d(55例,B组)、40 mg/d(55例,C组)治疗4周,比较3组患者的血脂水平、血管内皮功能相关指标及脑钠肽水平。结果治疗前后比较,不同剂量的阿托伐他汀10 mg,20 mg,40 mg四周后均可改善内皮功能及脑钠肽,其中C组四周后内皮功能相关指标一氧化氮(NO)水平明显高于A、B组(P<0.001),假血友病因子(vWF)水平明显低于A、B治疗组(P<0.001),脑钠肽的水平低于A、B治疗组(P<0.001),不良反应三组相似,改善了高血压病人的生存。结论降脂治疗可改善血管内皮功能及脑钠肽水平,40 mg阿托伐他汀改善内皮功能及脑钠肽水平下降明显,强化降脂治疗中对高血压病的防治具有肯定实用价值。

Objective To assess the safety and effect of atorvastatin on lipid-lowering and endothelial function. Methods 166 hyperlipidemic patients were assigned into three groups. Atorvastatin was given with different doses （Group A： 10mg qd, Group B ： 20 mg qd, and Group C： 40 mg qd）. The total period of treatment was 4 weeks. TC, TG, LDL-C, HDL-C, NO,vWF,BNP were determined before and 4 weeks after treatment. Results Different doses of atorvastatin all achieved good results, in which Group C was better than other two groups. TC, TG, LDL-C, FIB, and vWF were significantly decreased and NO, BNP increased（P〈0.05 or 0. 01）in Group C after 4 weeks of treatment. The side effects were similar in three groups Conclusion Atorvanstain can reduce lipid and improve endothelial function. High dose of atorvastatin is safe and has better effect for people in north China.