Ki-67在病理性瘢痕中的表达及意义

Clinic study of Ki-67 in differential diagnosis of pathological scars

目的研究Ki-67在病理性瘢痕以及正常皮肤中的表达。方法应用免疫组化方法检测47例增生性瘢痕,22例瘢痕疙瘩,16例正常皮肤组织Ki-67的表达。结果病理性瘢痕中Ki-67的表达明显高于正常皮肤,瘢痕疙瘩组织中Ki-67表达高于增生性瘢痕。结论瘢痕增生与细胞增殖增高呈正相关;Ki-67的表达可以作为鉴别增生性瘢痕与瘢痕疙瘩的指标之一。

Objective To evaluate the expression and its significance of Ki-67 in pathological scars and normal skins. Methods We investigated the expression of Ki-67 in 47 hyperplastic scars, 22 cheloid tissues, and 16 normal skins. Results The Ki-67 expression in pathological scars was significantly higher than that of normal skins; while the expression in cheloids was higher than that of hyperplastic scars. Conclusion There are different proliferation characters of fibroblast cells in hyperplastic scar, cheloids and normal skin. Scar hyperplasia is positively correlated with cell proliferation. Ki-67 expression could be useful in differential diagnosis of the hyperplastic scars and cheloids.