多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病

Dopamine and naloxone for the treatment of neonatal hypoxic-ischemic encephalopathy

目的观察应用小剂量多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床效果。方法91例HIE患儿随机分为2组,对照组45例给予吸氧,对症和支持等常规治疗,观察组46例在常规治疗基础上早期应用多巴胺5μg/kg.min,持续静脉滴注,纳洛酮0.1 mg/kg.d加入10%葡萄糖溶液30ml静脉滴注,一日一次,连用7天。结果观察组显效31例,有效15例,总有效率100%,对照组显效7例,有效26例,无效12例,总有效率73.3%。观察组总有效率高于对照组。结论应用小剂量多巴胺和纳洛酮治疗新生儿缺氧缺血性脑病可缩短疗程,降低病死率,改善预后。

Objective To observe the clinical effects of small dosage of dopamine and naloxione on neonatal hypoxic-ischemic encephalopathy （HIE ）. Methods 91 cases were divided into two groups randomly. Control group （45 cases） were given conventional therapy such as oxygen inhalation, symptomatic and support regimens. Experimental group （46 cases） were given dopamine （5μg/kg·min,ivgtt qd）, naloxone （0. 1mg/kg·d） plus 10% glucose 30ml at early stage on the base of conventional therapy. Results In experimental group, the therapeutic results were deemed excellent in 31 cases（67.4%）, good in 15 cases（32.6%）, and the total effective power was 100%. In control group, an excellent result achieved in 7 cases（15.6%）, good in 26 cases（57, 8%）, ineffective in 12 cases, and the total effective power was 73.3%. The effective power of the former is significant higher than the latter （P〈0.05）. Conclusion The therapy of small dosage of dopamine and naloxione injection is more effective, economical and has lower death rate and better prognosis than conventional therapies.