尼莫地平治疗脑梗死病人的疗效与多种血清酶变化

Effect of nimodipine in treating cerebral infarction and changes of serum emzymes

目的：探索尼莫地平治疗脑梗死病人的疗效及治疗前后多种血清酶的变化。方法：５２例脑梗死病人（男性２２例，女性３０例，年龄６７±ｓ９ａ），采用尼莫地平５０ｍＬ（１０ｍｇ）及羟乙基淀粉（７０６代血浆）５００ｍＬ，静脉滴注，ｑｄ×１５ｄ治疗；测定急性期和恢复期的７种血清酶（ＣＰＫ，ＬＤＨ，ＡＬＴ，ＡＳＴ，γ－ＧＴ，ＡＫＰ，Ａｍｙ－２）并以５２例同龄健康者作正常对照。结果：治疗１个疗程总有效率９２％。急性期（１～１０ｄ内）ＣＰＫ，ＡＳＴ明显增高，同恢复期及正常对照组比较，Ｐ值分别＜０．０１及＜０．０５；而γ－ＧＴ在急性期和恢复期的早期（发病３０～４０ｄ内）均高，同正常对照组比较，Ｐ＜０．０１。结论：尼莫地平加羟乙基淀粉治疗脑梗死疗效好，３种酶（ＣＰＫ，ＡＳＴ，γ－ＧＴ）的增高，对脑梗死病的诊断、治疗、预防提供了新的依据。

AIM: To investigate the effect of nimodipine on the levels of 7 serum enzymes in patients with cerebral infarction. METHODS: Fifty-two patients with cerebral infarction (M 22, F 30; age 67±s 9 a) were treated with nimodipine 50 mL( 10 mg) and hetastarch 500 mL, iv, drip, qd×15 d, seven enzymes (CPK, LDH, AST, ALT, γ-GT, AKP and Amy-2) in 52 patients and age-grade normal controls were studied in the acute and recovery periods of cerebral infarction. RESULTS: The total effective rates was 92%, CPK and AST increased (P<0.05) in the acute period (within 1-10 d), and they were higher than those in the convalescence (P<0.01); γ-GT was also higher in the acute and convalescence (within 30～40 d)(P< 0.01). CONCLUSION: Nimodipine has a good effective for treatment of cerebral infarction. And the increases of the CPK, AST and γ-GT provide a lead for diagnosis, treatment and prevention of cerebrovascular disease.