替托尼定与双氯芬酸治疗急性痉挛性肌痛的比较

Tizanidine vs diclofenac in treatment of acute painful muscle spasms

目的：临床观察和评估替托尼定治疗急性痉挛性肌痛的有效性和安全性。方法：急性痉挛性肌痛６０例，男性３９例，女性２１例，年龄３９±ｓ９ａ。随机均分为３组，分别服用替托尼定１ｍｇ，ｔｉｄ，替托尼定１ｍｇ加双氯芬酸２５ｍｇ，ｔｉｄ，双氯芬酸２５ｍｇ，ｔｉｄ，共１４ｄ，观察在接触时、运动时、休息时及夜间在服药前后疼痛程度的变化；并记录不良反应。结果：３组服药ｄ４的总有效率分别为８１％，８３％和６５％。前２组的不良反应为轻微的嗜睡（１０％）。结论：替托尼定较双氯芬酸更快、更有效地解除痉挛性肌痛（Ｐ＜０．０５），合适剂量为３ｍｇ／ｄ。

AIM: To evaluate clinically the efficacy and tolerability of tizanidine in the treatment of acute painful muscle spasms. METHODS: Sixty patients (M 39, F 21, age 39±s 9 a) with acute painful muscle spasms were randomly and equally divided into 3 groups. Tizanidine (3 mg/d), tizanidine (3 mg/d) plus diclofenac (75 mg/d), and diclofenac (75 mg/d) were respectively given orally to each of the groups for 14 d. The severities of pain on palpation, during movement, at rest and at night were evaluated before and after administrations of the drugs, and the adverse reactions were recorded. RESULTS: The effective rates on d 4 after administration in 3 groups were 81%, 83% and 65%, respectively. The adverse reactions of tizanidine recorded were drowsinesses (10%) which were mild and transient. CONCLUSION: Tizanidine relieves the acute painful spasms more effectively and quicklier than diclofenac does (P<0.05). The suitable dosage for patients is 3 mg daily.