乙酰吉他霉素治疗细菌性感染

Acetylkitasamytin in treating bacterial infections

目的：评价乙酰吉他霉素颗粒剂治疗细菌性感染的疗效。方法：轻、中型呼吸道感染，泌尿、生殖系感染，皮肤软组织感染１６２例。用乙酰吉他霉素颗粒剂治疗１０２例，男性５６例，女性４６例，年龄３８±ｓ１２ａ；用依托红霉素冲剂对照治疗６０例，男性３４例，女性２６例，年龄３６±１１ａ。２组受试者均采用口服给药。２种药成人剂量均为１．０ｇ／ｄ，儿童剂量均为２５～５０ｍｇ／（ｋｇ·ｄ），分３～４次服，疗程７～１０ｄ。结果：临床总有效率分别为７２％和６７％；致病菌清除率分别为７４％和６３％；不良反应率分别为１６％和３２％。结论：乙酰吉他霉素颗粒剂治疗轻、中型细菌性感染疗效好而且较安全。

AIM: To evaluate the efficacy of actylkitasamycin (AKM) granules in patients with bacterial infections. METHODS: One hundred and sixty-two patients with mild or moderale infections of respiratory tracts, urinary tracts, skin and soft tissue were observed. AKM was used to treat 102 patients (M 56, F 46, age 38±s 12 a); erythromycin estolate (EME) granules were used to treat 60 patients (M 34, F 26, age 36±11 a). Medicines were given 1.0 g/d po for adults and 25-50 mg/(kg·d) for children, tid or qid, respectively. RESULTS: The total clinical effective rates of AKM and EME were 72% and 67%, respectively. The bacterial eradication rates were 74% and 63%, respectively. Adverse reactions occurred in 16% and 32% of patients, respectively. CONCLUSION: Treatment of bacterial infections with AKM is effective and safe.