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普罗布考的药理学与药效学 被引量:3

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摘要 普罗布考可显著降低Ia及Ib型高脂血症病人的血胆固醇水平,其治疗纯合子型家族性高胆固醇血症作用和强抗氧化作用在降脂药中是唯一的,其抗主动脉及冠状动脉粥样硬化作用、消除黄瘤作用明显优于其他药,它的另一突出特点是副作用小。
出处 《新药与临床》 CSCD 北大核心 1997年第5期296-298,共3页
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参考文献3

  • 1Mao S J,Arterioscler Thromb,1991年,11卷,1266页
  • 2黄震华,新药与临床,1991年,10卷,169页
  • 3洪中立,中国药理学通报,1991年,7卷,95页

同被引文献16

  • 1陈临溪.丙丁酚防治动脉粥样硬化新进展[J].国外医学(生理病理科学与临床分册),1996,16(4):299-300. 被引量:6
  • 2Chamb Less LE, Heiss G, Folsom AR, et al. Associa tion of coronary heart disease incidence with carotid arte rial wall thickness and major risk factors: the Atheroscle rosis Risk in Communities (SRIC) study. 1987- 1993[J] .Am J Epidmiol,2002,146(6):483--492.
  • 3Salonen JT, Salonen R. Ultrasound B-Mode imaging in observational studies of atherosclerosis progression [J]. Circulation, 2003,87(SP3) :156-162.
  • 4Ishigami M, Yamashita S, Sakai N, et al. High--density lipoproteins from probucol - treated patient' s have increased capacity promote cholesterol efflux from mouse peritoneal macrophages load with acetylated low density lipoproteins[JJ. Eur J Clin Invest, 1997,27 (4) : 285 -- 294.
  • 5Schwartz CJ. Introduction--the probueol experience; A review of the past and a lock at the future[J]. Am J Cardiol, 2003,62:1-4.
  • 6Stiko- Rahm A, Hultgardh- Nil' son A, Regnestom J, et al. Natice and oxidiged LDL enhances production of PDGH AA and the surface expression of PDGF receptors in cultured human smooth muscle cells[J]. Arterioscler Thromb, 2002,12 : 1099- 1109.
  • 7Keaney JF, Xu A, Cunningham D, et al. Dietary probucol perverse endothelial function in cholesterolfed rabbits by limiting vascular oxidative stress and superoxide generation[J]. J Clin Invest, 2005,95:2520- 2528.
  • 8Parthasarathy S, Yong SG, Wifztu JL, et al. Probucol inhibitors oxidative modification of low denisity lipoprotein[J]. J Clin Invest, 2005,77:641--648.
  • 9Ku G, Doherty NS, Wolos JA, et al. Inhibition of endothelium--dependent relaxation in atherosclerotie rabbit aorta by probucol[J]. Am J Cardiol, 2006,62:888- 897.
  • 10温建华,王文信,方树青,陆辉明,黄飞龙,卢国华.降血脂药——普罗布考[J].中国新药杂志,1998,7(1):41-47. 被引量:13

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