汉化版SNOT-22评价慢性鼻-鼻窦炎患者生存质量的初步研究

Quality of life survey on patients with chronic rhinosinusitis by using Chinese version of the 22-item sinonasal outcome test （SNOT-22）

目的探讨慢性鼻-鼻窦炎（chronic rhinosinusitis，CRS）患者的健康相关生存质量（quality of life，QOL）状况。方法采用中文版医学结局研究简表36项（medical outcome study short-form 36-items，MOS SF-36）和汉化版鼻腔鼻窦结局测试22条（sinonasal outcome test-22，SNOT-22），对2006年12月至2007年3月住院接受鼻内镜手术的64例CRS患者和20名健康志愿者进行QOL调查，并对汉化版SNOT-22量表进行考核。结果汉化版SNOT-22量表的可行性、信度、效度和反应度等性质均通过考核（P值均〈0．01），其中影响健康最重要的5个问题依次是：鼻塞、流清鼻涕、嗅觉或味觉减退、头晕和鼻涕倒流。CRS患者术前鼻窦CT Lund-MacKay评分（10．19±6．37）与汉化版SNOT-22量表评分（33．77±14．90）的相关系数为0．233，表明二者之间有一定正相关性，但相关性不高。结论汉化版SNOT-22量表能有效评价CRS患者的QOL。CRS患者术前鼻窦CT Lund—Mackay评分与汉化版SNOT-22量表评分有一定正相关性。

Objective To explore the health-related quality of life （QOL） status of patients with chronic rhinosinusitis. Methods Sixty four patients with chronic rhinosinusitis and twenty healthy volunteers were enrolled, and their QOL scores were assessed by using SF-36 questionnaire （Chinese version） and SNOT-22 questionnaire translated into Chinese. Results The feasibility, reliability, validity, and responsibility of Chinese version of SNOT-22 questionnaire all passed the test. It showed that by Chinese version of SNOT-22 questionnaire the most five important items affecting health status were nasal obstruction, runny nose, loss of smell or taste, dizziness and post-nasal discharge respectively. The coefficient of correlation was 0. 233 between the SNOT-22 questionnaire and the Lund-MacKay CT score of patients with chronic rhinosinusitis. Conclusions Chinese version of SNOT-22 questionnaire can effectively assess the QOL status of patients with chronic rhinosinusitis. It showed less correlation between the SNOT-22 questionnaire and the Lund-MacKay CT score of patients with chronic rhinosinusitis.