早期帕金森病的中西医结合神经保护诊治思路

Diagnosis and Treatment Strategy for Neuroprotection with Combined TCM and Western Medicine in the Early Stage of Parkinson's Disease

神经保护是指一个过程,即某种治疗能有益地影响帕金森病(PD)的病理生理学基础,同"多巴胺拟似剂等对症疗法"相比,它可能推迟发病或延缓病情的发展。介绍存在亚临床或临床前期PD的证据,并对PD的早期诊断及中医、西医神经保护的现状进行了述评,提出早期PD中西医结合神经保护的防治策略,包括加强预防,增加循证医学证据,加强实验研究,利用新技术动态观察与PD有关的生物指标等,强调指出开发"多重靶标治疗神经退行性疾病的多功能药物"的中药复方设想。

Neuroprotecfion is a process in which a treatment beneficially affects the underlying pathophysiology of Parkinson＇s disease （PD）. Compared with dopamine agonists heteropathy, it could delay the onset or postpone the deveopment of disease. Evidences for the exist of sub - clinical or prc - clinical PD are introduced. The early diagnosis for PD, and the current status for neuroprotection with TCM and western medicine are stated. The diagnosis and treatment strategy for neuroproteetion with combined TCM and westem medicine in the early stage of PD arc put forward. These strategies inelude the enhancement of prophylaxis, the increase of evidence - based medicine proofs, the reinforce of experimental research and the dynamic observation of PD related biological indexes with new techniques. Emphasis is put on the presumption of developing eomplex prescription of traditional Chinese medicine that could work as multifunetion drugs with multi - targets for the treatment of neuro - degenerative disease.