豚鼠电刺激诱发前庭神经核场电位特征

Field Potentials Within Vestibular Nuclei Evoked by Electrical Stimulus in Guinea Pigs

目的探讨电刺激前庭诱发电位的特征。方法双银丝刺激电极放置于圆窗表面,在电刺激条件下采用玻璃微电极记录前庭神经核的场电位。结果电刺激诱发的前庭场电位主要由一个负波(N1)构成,其振幅随微电极在前庭神经核的位置而变化。电流和电压刺激的阈强度分别为0.59±0.07mA和0.90±0.50V,1.5倍阈强度的电流刺激时N1波的潜伏期为1.20±0.13ms,对间隔小于4ms的双刺激中的第二次刺激无反应或者反应减低。结论迷路刺激能有效地兴奋前庭神经诱发前庭神经核神经元的场电位,且电位相当稳定。

Objective To explore the characteristics of field potentials within vestibular nuclei evoked by electrical stimulus. Methods Double silver electrodes were placed on the surface of the round window. The vestibular nuclei field potential was recorded under the condition of electrical stimulus. Results The field potential consists of a negative wave （N1）, the threshold was 0. 59±0. 07 mA or 0.90±0. 50 V, the latency of N1 peak was 1.20± 0.13 ms. When double stimuli were applied, no response was noted. The second stimulus or the response was small if the time interval was less than 4 ms. Conclusion Evoked vestibular nuclei potential can be obtained by peripheral labyrinth electrical stimulus, which is quite stable.