金纳多对血管性痴呆大鼠认知功能及生长抑素表达的影响

Effects of Ginaton on Cognitive Function and Expression of Somatostatin in Vascular Dementia Rats

目的研究金纳多对血管性痴呆(vascular dementia,VD)大鼠认知功能及生长抑素(SS)表达的影响。方法采用结扎双侧颈总动脉方法制备慢性前脑缺血动物模型。将100只老龄大鼠随机分为假手术组、模型组和金纳多组。应用水迷宫及免疫组化方法对各组大鼠学习记忆及SS表达进行观察。结果模型组与假手术组学习记忆能力差异有统计学意义(P<0.05);与模型组比较,金纳多治疗30 d后大鼠学习记忆能力明显改善(P<0.05),SS阳性神经元表达增加(P<0.05)。结论金纳多可增加SS阳性神经元表达,改善VD大鼠学习记忆能力。

Objective To observe the effects of Ginaton on cognitive function and the expression of somatostatin （SS） positive cells in vascular dementia （VD） rats. Methods Model rats of chronic forebrain ischemia were carried out with permanent bilateral common carotid arteries ligation. 100 healthy 12-14 month-old Wister rats were randomly divided into 3 groups, the sham operated group （SOG）, model group （MDG）, Ginaton treated group （GTG）. Morris water maze was used to test the cognitive function of these rats. SS positive cells were observed through immunohistochemistry technique. Results By comparison with sham operated group, the learning and memory abilities of model rats were obviously impaired （P〈0.05）. After treatment of Ginaton for one month, by comparison with model group the learning and memory abilities of VD rats obviously improved （P〈0. 05）. The SS positive neurons also increased （P〈0. 05）. Conclusions Ginaton could increase the expression of SS positive cells accordingly to promote the learning and memory abilities of VD rats.