间歇依赖性长QT综合征扭转型室速/室颤(附八例报告)

Pause-dependent LQTS-TdP-VF

间歇依赖性LQTS患者发生TdP后少数可恶化成VF。对心脏病患者凡心动过缓，特别是伴低血钾、低血镁者，使用可引起QT间期延长药物者，有晕厥史，尤其有TdP史者，均应视为TdP高危患者，而行严密心电及血电解质监测，注意TdP的预兆性征象以期早诊断、早防治。当有关致病因素合并存在时可致病情复杂化及病程绵延。强调综合治疗，予镁盐、钾盐治疗时疗程宜长，以防病情反复。

A few patients with pause-dependent LQTS-TdP could be deteriorated into ventricular fibrillation. Patients with severe bradycardia, hypokalemia and hypomagnesemia, with administration of theQT-interval prolonging drugs,with syncoPe,especially with the previous history of TdP,should be considered as high-risk ones, therefore close cardiac and blood electrolytes monitering are required in order tocheck out ominous prodrome of TdP,for early diagnosis, prevention and treatment. 8 patients have beenobserved in this article. We got conclusion that the coexistence of related pathogenic factors could makeclinical condition complicated and prolongation of course of disease. Combination treatment was emphasizedin this article. The therapeutic course with potassium and magnesium should be longer than that of conventional treatment for prevent the recurrence of TdP.