再狭窄的细胞和分子生物学(一)

The Cellular and Molecular Biology of Restenosis

冠状动脉血管成型术后的再狭窄是心血管病防治研究的一个重点和热点，本文结合我们研究所近5年来的研究工作和国内外研究进展，就再狭窄形成的细胞和分子生物学机制，分为再狭窄的形成过程、生物活性物质和生长因子、平滑肌细胞增殖和凋亡、细胞信息传递和转录调节、癌基因和抗癌基因及再狭窄的基因治疗等六个方面进行较系统和全面的综述。

The problem of restenosis after percutaneous transluminal coronary angioplasty (PTCA)remains unsolved. The aim of this article is to review the cellular and molecular biological mechanisms ofrestenosis after angioplasty. It included: (1)The process of restenosis formation;(2)Bio-active peptide andgrowth factors; (3)Smooth muscle cens proliferation and apoptosis;(4)Intracellular signal transduction andtranscriptional control; (5)Oncogene and antioncogene; (6)Gene therapy of restenosis.