非小细胞肺癌组织中S100A4蛋白的表达及临床意义

Expression of S100A4 Protein in Non-small Cell Lung Cancer and Its Clinical Significance

目的:探讨非小细胞肺癌(NSCLC)组织中S100A4蛋白的表达及其临床意义。方法:应用免疫组化SP法检测S100A4蛋白在90例NSCLC组织中的表达,分析其与临床病理学特征的关系。结果:S100A4蛋白在NSCLC的表达阳性率为64.4%;S100A4蛋白的表达阳性率在鳞状细胞癌与腺癌、腺鳞癌、大细胞癌之间差异有显著性(P<0.05)。S100A4蛋白的表达与NSCLC分化程度、淋巴结转移和年龄有关(P<0.05)。结论:S100A4蛋白在NSCLC中的表达与肿瘤的进展密切相关;S100A4蛋白可作为判断NSCLC生物学行为、预测转移趋势及指导临床治疗的有价值的标记物。

Objective： To investigate the expression and clinical significance of S100A4 protein in nonsmall cell lung cancer（NSCLC）. Methods： Immunohistochemical staining（SP method）for detection of the expression of S100A4 protein was performed in 90 cases of NSCLC to analyze association of S100A4 protein with clincopathological characteristics. Results： The positive expression rate of S100A4 protein was 64.4 % in NSCLC. There was a significant difference of the expression rate of S100A4 protein among adenocarcinoma, adenosquamous carcinoma, large cell lung cancer and squamous cell carcinoma（P〈0.05）. The positive expression rate of S100A4 protein was significantly related with lymph node metastasis, degree of differentiation and age （all P〈 0.05）. Conclusion： Expression of S100A4 protein is significantly associated with tumor progression in NSCLC, and it could be used a valuable marker in predicting biological behavior and metastasis, and directing clinical therapy of NSCLC.