神经损伤影响骨折愈合速度机制研究的进展

Research progress of mechanism of nerve injuries affecting speed of fracture healing

在临床实践中观察到骨折合并脑外伤患者骨痂过度生长,甚至在肌肉中出现异位骨化,骨折愈合明显加快,但其发生机制尚不清楚。骨折愈合是一个复杂的过程,受到机体大环境以及局部小环境的多层面、多途径调节,而且在这个过程中有许多生长因子的参与,是骨折愈合的基础。本文通过综合近年相关研究进展,回顾分析神经损伤特别是颅脑外伤后对骨折相关生长因子、即刻早期基因的影响,探讨神经损伤影响骨折愈合速度的可能机制。

In patients who have sustained a traumatic brain injury with an associated extremity fracture, there is often a clinical perception that the rate of new bone formation around the fracture site is increased. An overgrowth of callus is observed and ectopic ossification even occurs in the muscle, but the mechanism remains unclear. It is a complex process influenced by multi-level and multi-route regulations of the general and local environments in the body,and many growth factors participate in this process ,which is the base of bone healing. In order to explore the possible mechanism underlying influence of nerve injuries especially traumatic brain injury on speed of bone healing, we reviewed the studies on expression changes of growth factors,immediate early genes after traumatic brain injury.