一种狼疮性肾炎的临床活动性指数

A clinical activity index of lupus nephritis

筛选与狼疮性肾炎疾病活动程度相关性最好的临床与实验室指标，并建立一种疾病活动性的计分方法。方法以临床医师的判断作为疾病活动程度的外部标准，对１１７例狼疮性肾炎患者的资料进行单因素相关分析和多元回归分析。结果筛选出１４个最能提示疾病活动性的参数，并以各参数在多元回归分析中的回归系数作为其各自的加权分（略加简化），建立了一种狼疮性肾炎疾病活动程度的计分方法，即活动性指数。结论这一活动性指数能较简便、合理、有效地测定狼疮性肾炎的活动程度。

Objective To identify the clinical and laboratory parameters that best correlates with disease activity of lupus nephritis, and to estabolish a measurement of disease activity. Methods Univariate analysis and multivariate regression were performed on data of 117 patients with lupus nephritis, with the physicians global assessment of disease activity as the external criteria. Results A scoring system (the activity index) was constructed including 14 selected variables most indicative of disease activity, weighted (with some simplification) according to their respective regression coefficients in the multivariate regression. Conclusion The activity index appears to be simple, rational and effective for measuring the activity of lupus nephritis.