尿视黄醇结合蛋白与糖尿病肾病

The correlation between urinary retinol binding protein and diabetic nephropathy

为了探讨尿视黄醇结合蛋白（ＲＢＰ）与糖尿病肾病的关系。方法用酶联免疫法测定了８７例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者的尿ＲＢＰ，同时测定尿Ｎ乙酰βＤ氨基葡萄糖苷酶（ＮＡＧ）、β２微球蛋白（β２ｍ）。结果糖尿病患者尿ＲＢＰ均较正常对照组增高，尿ＲＢＰ与尿Ａｌｂ、尿ＮＡＧ和β２ｍ呈正相关。结论在糖尿病早期阶段，肾小管功能会受到损害，尿ＲＢＰ可作为诊断早期糖尿病肾病的敏感指标。

Objective To study the relationship between urinary retinol binding protein (RBP) and diabetic nephropathy. Methods The concentration of RBP in the urine of NIDDM was measured by ELISA. The concentration of N acetyl beta D glucosamindase (NAG) and beta 2 microglobulin (β 2 m) in the urine were also measured. Results The urine RBP in all three groups was significantly higher than that in control group. The urine RBP related positively to urine Alb、urine NAG and β 2 m. Conclusion Renal tubular function has been damaged in the early diabetic nephropathy and urinary RBP is an indicator of the diagnosis of the early diabetic nephropathy.