摘要
目的了解慢性肾功能衰竭(CRF)患者血浆P物质(SP)、心钠素(ANP)含量变化与肾功能的关系。方法采用放射免疫分析法检测正常对照组及CRF组血液透析前后SP、ANP,同时测定血清肌酐(Scr)。结果(1)透析前SP显著高于正常对照组(P<001),透析后SP高于透析前(P<005);SP透析前与Scr呈正相关(r=066,P<005),SP透析后与Scr呈负相关(r=-046,P<005);(2)透析前ANP显著高于对照组(P<001),透析后ANP显著低于透析前(P<005),ANP透析前后与Scr呈正相关(r=082,P<005);(3)透析前后SP变化值与ANP变化值呈负相关(r=-048,P<005)。结论CRF患者血浆SP、ANP含量的变化与肾功能的改变有较明显的相关性。
Objective To investigate the relationship between plasma P substance (SP)、 atrial natriuretic peptide (ANP) and renal function in chronic renal failure (CRF). Methods SP and ANP were measured by radioimmunoassay in normal control and CRF before and after hemodialysis (HD), serum creatinine (Scr) was determined simultaneously. Results (1)SP before HD was significantly higher than that of control (P<0 01) and significantly lower than that after HD (P<0 05). There was a positive correlation between SP before HD and Scr(r=0 66, P<0 05), a negative correlation between SP after HD and Scr (r=-0 46,P<0 05). (2)ANP before HD was significantly higher than that of control (P<0 05). There were positive correlations between Scr and ANP before and after HD (r=0 82,P<0 05). (3)There was a negative correlation between the quantitative difference of SP and that of ANP before and after HD (r=-0 48,P<0 05). Conclusion There is a significant correlation between the change of plasma SP、ANP concentrations and Scr level in CRF patients.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1997年第4期236-238,共3页
Chinese Journal of Nephrology
关键词
慢性
肾功能衰竭
P物质
心钠素
肾功能
Chronic renal failure P substance Atrial natriuretic peptide