摘要
目的观察不同剂量卡维地洛(CAR)对心肌梗死(MI)后大鼠左室重构及心肌细胞凋亡的影响。方法结扎大鼠冠状动脉前降支,随机分成三组:MI组,术后不用药,卡维地洛大剂量组(HCAR组),卡维地洛小剂量组(LCAR组),术后2d分别给予卡维地洛10 mg/kg和1.25 mg/kg。另外不手术不用药组为假手术组(SH组)。6周后测定左室重构指标及心肌细胞凋亡计数。结果卡维地洛用药组与MI组比较,左室重构明显改善,心肌细胞凋亡量明显减少,且有剂量依赖,大剂量组优于小剂量组。结论卡维地洛可改善AMI后大鼠的左室重构,并有剂量依赖性,减少心肌细胞凋亡可能是其重要因素之一。
Objective To assess the dosage-effect pattern of carvedilol on LV remodeling and apoptosis in myocytes after MI. Methods Sham operated rats（SH） were selected randomly before conduction of AMI. after conduction of AMI, the surviving rats were randomly assigned to one of the following groups ： MI group （AMI without carvedilol） ;hige-dose carvedilol group （carvedilol 10mg/kg/day） and low-dose carvedilol group（1.25 mg/kg/day）,at the end of 6-week therapy, parameters of LV remodeling and apoptosis were measured. Results Comparing to MI group, LV remodeling decreased significantly and apoptosis reduced in carvedilol group in a dosage-effect pattern. Conclusions Carvedilol prevented LV remodeling, and anti-apoptosis acteveties of carvedilol may play an important role in this progression.
出处
《中国分子心脏病学杂志》
CAS
2007年第6期332-334,共3页
Molecular Cardiology of China
关键词
卡维地洛
左室重构
凋亡
Carvedilol
Left ventricular remodeling
Apoptosis
