盐藻提取物对小鼠肿瘤免疫功能的影响

Effects of Extracts of Dunaliella Salina on Tumor Immunity in Mice

本实验研究观察了盐藻提取物（EDS）对小鼠抗肿瘤免疫的影响。结果显示，高和中剂量的EDS能显著地（P＜0．05）提高正常和荷瘤小鼠的脾细胞对ConA反应的增殖活性及腹腔巨噬细胞产生肿瘤坏死因子活性。此外，EDS还能减少Lewis肺癌肺转移灶数。这些发现提示，口服EDS的抗肿瘤作用可能是通过增强机体抗肿瘤免疫而实现的。

The effects of Dunaliella salina (EDS) on tumor immunity were observed in mice. The results revealed that in high and medium doses of EDS significantly (P<0.05) enhanced proliferative response to Con A of spleen cells and tumor necrosis factor activity produced by peritoneal macrophage not only in normal mice, but also in tumor-bearing mice. In addition, EDS could markedly reduce spontaneous pulmonary metastases of Lewis lung carcinoma (P<0. 05) compared to the control group. These findings suggested that antitumor action by oral administration of EDS may be due to improving antitumor immunity.