花粉症快速免疫治疗前后血清特异性抗体水平测定

Changes in the levels of artemisia pollen specific antibodies during rush immunotherapy for pollinosis

动态观察花粉症快速免疫治疗前后血清特异性ＩｇＥ、ＩｇＧ和ＩｇＧ４抗体的变化。对４９例进行快速免疫治疗的花粉症患者采用酶联免疫吸附测定法（ＥＬＩＳＡ）测定血清ＩｇＥ、ＩｇＧ和ＩｇＧ４。结果：花粉症患者血清特异性ＩｇＥ、ＩｇＧ和ＩｇＧ４较健康对照组明显升高（Ｐ＜０．００１和Ｐ＜０．０５）。免疫治疗６周后ＩｇＧ和ＩｇＧ４抗体水平较治疗前明显升高（Ｐ＜０．００１和Ｐ＜０．０５），ＩｇＥ抗体无明显变化。证实快速免疫治疗在临床症状改善的同时血清特异性ＩｇＧ水平快速升高。

Artemisa pollen specific immumoglobulins (IgG 4,IgG and IgE) were evaluated by means of ELISA during rush immunotherapy in 49 patients with pollinosis. The results showed that six weeks after the beginning of immunotherapy, the levels of specific IgG 4 ( P <0 05) and IgG ( P <0 001) antibodies were significantly higher than those of patients prior to receiving rush immunotherapy. These results suggest that rush immunotherapy may result in a rapid increase in IgG antibody levels, and high specific IgG level may implicate a clinical improvement in allergic patients due to the rush immunotherapy.