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DNA链间交联的修复与辐射敏感性 被引量：3

Repair of DNA interstrand cross-links and its＇ role in radiation sensitive
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摘要 实体肿瘤中存在大量的乏氧细胞。辐射可以导致这些乏氧细胞产生DNA链间交联（DNA interstrand cross—links，ICL）。ICL对细胞具有潜在的致死性毒性作用。细胞通过核酸切除修复、同源重组等方式修复ICL。但这种修复需要数小时才能完成。抑制ICL修复，有可能成为提高辐射敏感性的一种策略。 There are a lot of hypoxia cells in tumor tissue. These cells trend to induce the DNA interstrand cross-links （ICL） under radiation. ICL has potential lethal effect on the cells. Repair of ICL need a period of hours. It is possible to be a strategy in enhance of radiation sensitive by block the repair of ICL.
作者 郭阳
机构地区 天津环湖医院放疗科
出处 《国际放射医学核医学杂志》 2007年第6期371-372,376,共3页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 DNA损伤 DNA修复 辐射耐受性 DNA链间交联 DNA damage DNA repair Radiation tolerance DNA interstrand cross-links
分类号 R [医药卫生]
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参考文献15

  • 1Jaruga P, Theruvathu J, Dizdaroglu M, et al. Complete relese of (5'S) -8,5'-cyclo-2'deoxyadenosine from dinucleotides,ologodeoxynucleot ides and DNA with other oxidatively induced DNA lesions. Nucleic Acids Res, 2004, 32: e87.
  • 2Hong IS, Ding H, Greenberg MM. Oxygen independent DNA interstrand cross-link formation by a nucleotide radical. J Am Chem Soc, 2006, 128(2) : 485-491.
  • 3Cecchini S, Girousrd S, Huels MA, et al. Interstrand cross-links; A new type of gamma-ray damage in bromodeoxyuridine-substiuted DNA. Biochemistry, 2005, 44(6): 1932-1940.
  • 4Cecchini S, Masson C, La Madeleine C, et al. Interstrand cross-link induction by UV radiation in bromodeoxyuridine-substituted DNA: dependence on DNA conformation. Biochemistry, 2005, 44( 51 ): 16957-16966.
  • 5Lambert S, Mason SJ, Barber LJ, et al. Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links. Mol Cell Biol, 2003, 23(13): 4728-4737.
  • 6Sridharan D, Brown M, Lambert WC, et al. Nonerythroid alphaⅡ spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. J Cell Sci, 2003, 116 (Pt 5): 823-835.
  • 7D'Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer, 2003, 3(1): 23-34.
  • 8Collis SJ, Barber LJ, Ward JD. C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. DNA Repair (Amst), 2006, 5(11): 1398-1406.
  • 9Rothfuss A, Grompe M. Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol Cell Biol,2004,24(1):123-134.
  • 10Niedernhofer LJ, Odijk H, Budzowska M, et al. The structure-specific endonuclease Erecl-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol, 2004, 24 (13): 5776-5787.

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国际放射医学核医学杂志
2007年 第6期

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