慢性阻塞性肺病血栓前状态的检测及其临床意义

The Detection and Significance of Prethrombosis State in COPD Patients

目的:观察交联纤维蛋白二聚体(D-D)含量,探讨凝血及纤溶机能紊乱与慢性阻塞性肺病(COPD)发生发展间的关系及临床意义。方法:选择我院ICU及呼吸科住院的慢性阻塞性肺病急性发作期患者25例,缓解期的慢性阻塞性肺病患者24例,及28例健康体检者,空腹安静时抽取肘静脉血,采用酶联免疫吸附双抗体夹心法测定交联纤维蛋白二聚体(D-D)含量。结果:以均数±标准差(x±sd)表示,t检验进行统计学处理。结论:COPD患者急性发作期体内存在凝血及纤溶系统平衡失调,处于血栓前状态。因此,D-D的检测对于COPD的发展及治疗具有重要的临床意义。

Objective： To observe the content of d - dimer, investigate their relations between the disorder of hemoglutintion filament dissolve function and COPD＇s development, progression, clinical significance. Method ： We collected 25 acute attack hospitized patients in ICU and in respiratory wards. 24 alleviated pa- tients and 28 normal health physical examined patients. Adopted blood in elbow vein when they were peaceful and on an empty stomach. Examinated the content of d - dimer with ELISA method. The result is expressed by x ＋ sd ,T - test was statistically analyzed. Result： There is balance disorder between hemoglutintion and filament dissolve system among the acute attacked COPD patients, It is prethrombosis state, therefore,the test of d - dimer has the vital clinical significance to the development and treatment of COPD.