氨溴索对慢性阻塞性肺疾病患者氧化应激的影响

Effect of Ambroxol on Oxidative Stress in the Patients with COPD

目的:研究氨溴索针剂对慢性阻塞性肺疾病(COPD)急性加重期患者氧化与抗氧化能力的影响。方法:COPD急性加重期患者,采用氨溴索针剂治疗,检测患者血清丙二醛(MDA)、超氧化物歧化酶活性(SOD)水平。并比较两组患者总有效率。结果:氨溴索治疗显著降低患者血清MDA含量,显著增加SOD水平,总有效率提高。结论:氨溴索能减轻COPD急性加重期患者氧化应激程度,提高患者抗氧化能力,对COPD患者有一定辅助治疗价值。

Objective： To investigate the effect of Ambroxol on oxidative stress in the patients with chronic obstructive pulmonary disease（COPD）. Method： Patients with COPD were treated with Ambroxol. The level of serum MDA, SOD were determined. Result ： After the application of Ambroxol, MDA content decreased significantly, and the level of SOD increased significantly. Conclusion： Ambroxol treatment could ameliorate the oxidative stress in the patients with COPD.