窒息新生儿体内三大抗凝因子活性的研究

The Study of the Activity of Plasma Protein C Protein S and Antithrombin-Ⅲ in Asphyctic Neonates

目的:探讨窒息缺氧对新生儿血浆蛋白C、S、抗凝血酶Ⅲ(AT-Ⅲ)活性的影响。方法:我院新生儿科于2004年9月至2005年12月采用发色底物法分别测定出生时、3d、7d的56例窒息新生儿血浆蛋白C、抗凝血酶Ⅲ活性,用凝固酶法测定蛋白S的活性。正常对照组为同期出生的健康新生儿51例。结果:出生时、3d窒息组与正常对照组血浆蛋白C、S、抗凝血酶Ⅲ活性均有不同程度下降,窒息组下降明显,其差异有非常显著意义(P均<0.01)。结论:窒息新生儿3d内血浆蛋白C、S、抗凝血酶Ⅲ活性明显降低,并与窒息的程度有关,血浆蛋白C、S、抗凝血酶Ⅲ降低明显窒息愈重,常合并多个组织器官损害,但未达到DIC标准。

Objective： To explore the dynamic changes of protein C, Protein S and antithrombin Ⅲ in asphyctic neonates. Method： From Sep. 2004 to Dec. 2005, respectively, on the time of being born 3rd day and 7th day, the activity of protein C and AT - Ⅲ of 56 cases with asphyctic neonates and 51 cases normal newborn infants, were detected by illuminant substrate method, while protein S was detected by coagulatire method. Result： The activity of protein C, protein S and AT - Ⅲ on the time of being born and the third, the seventh day reduced in all observed newborn infants, while, the group of asphyctic neonates was more significandy lower than the normal new born infants. There was no significant difference between the two groups on the 7th day. Conclusion ： The present data suggests that the changes of the protein C, protein S and AT - Ⅲ in 3 days are related to severity of asphyxia, the more severe asphyxia is, the more lower the activity of protein C protein S and AT - Ⅲ, usually, combined with the injury of multi - organs, while it has not been reached the standards of DIC.