摘要
目的目前强制性运动疗法广泛地应用于康复领域,并被证实能够有效地促进肢体功能恢复,但其确切的机制尚不清楚。方法应用免疫组化及ELISA方法并结合行为学探讨了强制性运动疗法对脑缺血后内源性神经干细胞及间质细胞源性因子-1表达的影响。结果发现脑缺血后强制性运动疗法能够促进患侧肢体运动功能的恢复,增加大鼠侧脑室下区新生神经干细胞的数量,并能提高脑组织基质细胞衍生因子-1蛋白的表达水平。结论强制性运动疗法可能通过影响脑缺血后的神经再生过程从而达到增强中枢神经系统修复能力的作用。
Objective Constraint-induced movement therapy （ CIMT ） is effective to improve the functional recovery after stroke. Method This study investigated the effects of CIMT on the regulation of endogenous neural stem cells and the expression of stromal cell-derived factor 1（SDF-1） using immunohistochemistry and ELISA combined with behavioral tests. Results Following stroke, CIMT can improve the functional recovery, increase the number of neural stem cells in subventricular zone and increase the level of stromal cell-derived factor 1 protein. Conclusion CIMT may enhance the self-repair of central nervous system by stimulating the neurogenesis after stroke.
出处
《中国血液流变学杂志》
CAS
2007年第4期521-524,共4页
Chinese Journal of Hemorheology
基金
国家自然科学基金青年基金资助项目(30500611)
教育部留学回国人员科研启动基金资助项目(教外司留[2006]331号)
