血清fPSA、tPSA及其比值测定在诊断前列腺癌的价值

The Value of Serum tPSA、fPSA Concentration and the Ratio of fPSA/tPSA in the Diagnosis of Prostate Cancer

目的探讨血清中fPSA、tPSA及其比值测定在诊断前列腺癌的价值。方法用ABBOTT公司生产的Axsym全自动免疫分析系统的微粒子酶免疫分析法(MEIA)测定50例正常人,112例前列腺增生和29例前列腺癌患者血清fPSA、tPSA及fPSA/tPSA比值进行分析。结果以tPSA>4.0μg/L、fPSA>0.93μg/L和fPSA/tPSA比值<0.11作为前列腺癌界定值及判别指标,其敏感性、特异性分别为tPSA93.1%、62.9%;fPSA89.7%、66.3%;fPSA/tPSA 93.1%、93.1%,后者特异性显著高于tPSA和fPSA(P<0.01))。结论fPSA/tPSA比值在鉴别前列腺癌与前列腺增生中有重要的临床应用价值。

Objective To explore the specific prostate antigen （PSA） valuve in diagnosing prostate cancer by integrally testing the serum total PSA （tPSA）,free PSA（fPSA） as well as ratio of fPSA/tPSA.Methods The serum tPSA and fPSA of 50 normal people, 112 with benign prostate hyperplasia （BPH） and 29 with prostate cancer were measured by particulate enzyme immunoassay （MEIA） of Axsym produced by ABBOTT company, to find out the ratio offPSA/tPSA were analyzed.Results When using tPSA〉4.0 μg/L,fPSA〉 0.93μg/L and the ratio offPSA/ tPSA 〈0.11 only as prostate cancer diagnostic criterion, the specificity and the positive detectable rate were tPSA 93.1%,62.9%;fPSA 89.7%,66.3% and fPSA/tPSA 93.1% ,93.1%,respectively, its positive detectable rate siganificanfly higher than that of tPSA and fPSA（P〈0.01）.Conclusion The ratio of fPSA/tPSA there is important clinical application value in differentiating the prostate cancer and the benign prostate hyperplasia（BPH）.