丙戊酸钠合并氯丙嗪治疗精神分裂症的对照研究

A comparative study of valproate with chlorpromazine in the treatment of schizophrenia

目的观察丙戊酸钠合用氯丙嗪治疗精神分裂症的疗效与不良反应。方法符合CCMD-3诊断标准的精神分裂症住院患者,丙戊酸钠合用氯丙嗪组(研究组)35例,单用氯丙嗪组(对照组)31例。以PANSS、CGI、TESS量表评定观察12周。结果研究组总体疗效自第2周起明显优于对照组(P<0.05),其中研究组兴奋症状分及攻击因子分自第4周起缓解明显优于对照组(P<0.05)。研究组较对照组副反应较少且程度较轻(P<0.05)。结论丙戊酸钠合并氯丙嗪治疗精神分裂症疗效肯定,安全性与耐受性较好。

Objective To study the efficacy and safety of valproate combined with chlorpromazine in the treatment of schizophrenia. Methods A total of 66 inpatients meeting the criteria of CCMD--3 for schizophrenia were divided into two groups, 35 cases were treated with valproate combined with chlorpromazine（study group） and 31 cases were treated with chlorpromazine（control group）for 12 weeks of treatment. PANSS,CGI and TESS were used to measure the efficacy and safety. Results The total efficacy of study group was significantly better than that of control group including excitement factor and aggressive factor（P〈0.05）. The study group had fewer side effects than control group（P〈0. 05）. Conclusion Valproate combined with chlorpromazlne shows a satisfactory effect and safety in the treatment of schizophrenia.