辛伐他汀对老年2型糖尿病血脂、超敏C反应蛋白的影响

The effection of simvastatin to serum lipide,high sensitivity C-reactive protein in elderly type 2 diabetic patients

目的:探讨常规剂量、短疗程辛伐他汀对老年2型糖尿病(T2DM)患者血脂、C反应蛋白(CRP)的影响。方法:60例LDL-C≥2.6mmol/L的老年T2DM患者随机分为两组:辛伐他汀组采用辛伐他汀20mg/d+常规治疗,对照组采用常规治疗,于治疗前及治疗后2周分别测定血脂、超敏C反应蛋白(hsC-RP)等指标。结果:辛伐他汀组治疗2周后TC、TG、LDL-C、hsC-RP较治疗前显著下降,差异具有统计学意义(P<0.05),且hsC-RP下降与TC、TG、LDL-C下降无相关性;对照组上述指标较治疗前虽有下降,但差异无统计学意义。所有受试者均未发现血清转氨酶(ALT)、肌酸激酶(CK)升高及肾功能损害。结论:常规剂量、短疗程辛伐他汀可显著降低老年T2DM患者LDL-C水平,而且具有独立于降脂作用之外的显著降低hsC-RP水平的作用,从而具有防治老年T2DM患者动脉粥样硬化的发生、发展的作用,且安全性良好。

Objective： To research the effect of simvastatin to serum lipid,high sensitivity C-reactive protein （hsC-RP） and safety in elderly type 2 diabetic patients.Methods： Sixty type 2 diabetic patients,aged 〉60,and LDL-C ≥2.6 mmol/L, were randomly divided into two groups. 30 patients were involved as simvastatin group treated with simvastatin 20 mg/d and conventional therapy for 2 weeks. Others only treated by conventional therapy as control were convention group.Serum levels of TC,TG,LDL-C,hsC-RP were measured before and after treatment.Results：After 2 weeks,the levels of TC,TG, LDL-C,hsC-RP reduced significantly in the simvastatin group than those of before （P〈0.05）.In addition,the decrease of hsC-RP was no relation with the decrease of TC,TG ,LDL-C . The levels of TC,TG,LDL-C,hsC-RP decreased after 2 weeks in the convention group, but no significant change were found comparing to the beginning of the study（P〉0.05）.The levels of serum transaminase, creatine phosphokinase and creatinine in all tested patients kept normal although the study. Conclusion： Usual-dose and short-period administration of simartatin could markedly postpone the atherosclerosis by significantly decrease the LDL-C and hsC-RP. It was safe in elderly type 2 diabetic patients.