帕罗西汀单用与帕罗西汀合并喹硫平对强迫症疗效的对照研究

A comparative study of paroxetine combining with quetiapine in the treatment of obsessive-compulsive disorder

目的探讨帕罗西汀合并喹硫平治疗强迫症的疗效。方法50例强迫症患者随机分为帕罗西汀组和帕罗西汀合并喹硫平组,疗程8周。采用强迫症量表(Y-BOCS),汉密尔顿焦虑量表(HAMA),汉密尔顿抑郁量表(HAMD),评定疗效。结果治疗结束时两组Y-BOCS,HAMA,HAMD的评分均显著下降,而合并喹硫平组更明显。结论帕罗西汀合并喹硫平治疗强迫症可以提高疗效。

Objective To investigate the efficacy of paroxetine combining with quetiapine in the treatment of obsessive-compulsive disorder（OCD）. Methods A total of 50 patients with OCD were randomly treated with paroxetine only or paroxetine combining with quetiapine . The efficacy was measured with Yale-Brown obsessive compulsive scale（Y-BOCS）, Hamilton anxiety scale（HAMA） and Hamilton depression scale （HAMD）. Results There were significant differences between two groups in the reducing rate of Y-BOCS, HAMA and HAMD. Conclusion It is suggested that paroxetine combining with quetiapine could improve efficacy in the treatment of OCD.