环氧化酶与脑缺血再灌注损伤研究进展

Study Progress of Cyclooxygenase and Brain Ischemical Reperfusion Injury

环氧化酶是催化花生四烯酸生成前列腺素和血栓素的限速酶,有环氧化酶1、环氧化酶2、环氧化酶3共三种同工酶。近年来的研究表明,环氧化酶尤其是环氧化酶2与脑缺血再灌注损伤发生、发展密切相关。可能的机制涉及破坏血栓素/前列环素平衡、增加氧化应激损伤、加重兴奋性氨基酸毒性、促进细胞凋亡和增强神经炎性反应。对其拮抗剂的研究有望为脑缺血再灌注损伤治疗找到新的途径和方法。

Cyclooxygenase （COX） is a rate-limiting enzyme which catalyzes arachidonic acid to produce prostaglandin and thromboxane. There are 3 isoenzymes, COX-1, COX-2 and COX-3. The recent studies showed that COX, especially COX-2, has elosc correlation with the genesis and development of brain ischemical reperfusion injury.The possible mechanism maybe lie in destroying the balance between thromboxan/prostacyclin, increasing oxidative stress injury, aggravating toxicity of excitatory amino acids, improving apoptosis and strengthening nervous inflammatory reaction. The study for its antagonists may be promising in finding novel pathways and approaches in the treatment CIRI.