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口腔扁平苔藓中caspase-8和受体作用蛋白的表达及其与细胞凋亡的研究

Expressions of Caspase-8,RIP and Their Relationship with Apoptosis in Oral Lichen Planus
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摘要 口腔扁平苔藓是常见的口腔黏膜慢性炎症性疾病。在临床上主要表现为口腔黏膜白色斑块或条纹,其病理学特征为基底细胞液化变性,固有层淋巴细胞带状浸润。目前认为,口腔扁平苔藓是由T细胞介导的自身免疫性慢性炎症性口腔黏膜疾病。其发生与细胞凋亡关系密切。半胱氨酸天冬氨酸蛋白酶8和受体作用蛋白参与了细胞的凋亡过程。 Oral lichen planus（OLP）is a common, chronic inflammatory mucosal disease. Its main clinical manifestation is white plaque or the stripe in oral mueosa. The histopathologic features of OLP are liquifaction degeneration of basal cells, band-like infiltration of lymphocyte in lamina propria. OLP was considered to be a kind of autoimmune chronic inflammatory mucosal disease, of which the genesis have close relationship with apoptosis. Caspase-8 and RIP participate in cell apoptotic process.
作者 史永建 沈丽佳
机构地区 暨南大学医学院口腔医学系
出处 《医学综述》 2008年第2期183-185,共3页 Medical Recapitulate
基金 广东省医学科研基金资助项目(A2006338)
关键词 口腔扁平苔藓 半胱氨酸天冬氨酸蛋白酶-8 受体作用蛋白 细胞凋亡 Oral lichen planus Cysteinylasparate specific proteinase-8 Receptor interacting protein Apoptosis
分类号 R781.5 [医药卫生—口腔医学]
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参考文献22

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二级参考文献8

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医学综述
2008年 第2期

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