1Brozinick JtJr, Mccoid SC, Reynolds TH, et al. GLUT4 overexpression in db/db mice dose - dependently ameliorates but is not a lifelong cure [ J]. Diabetes,2005,50:593
2Watson R T, Pessin J. IntraceUular organization of insulin signaling and GLUT4 translocation[ J]. Recent Prog Horm Res ,2001,56 : 175
3Bryant N, Govers R, James D, et al. Regulated Transport Of The Glu2cose Transporter GLUT4 [ J ]. Nat Rev Mol Cell Biol, 2002,3 (4) :267
4Watson R, Pessin J. Intracellular organization of insulin signaling and GLUT4 translocation [ J ]. Recent Prog Horm Res,2001,56 : 175
5Bell G,Polonsky K. Diabetes mellitus and genetically programmed defects inβcell function [J]. Nature ,2001,414:788
6Fryer. L, Foufelle F, Barnes K, et al. Characterization of the role ofthe AMP2activated protein kinase in the stimulation of glucose transportin skeletal muscle cells[ J]. BiochemJ ,2002,363( Pt 1 ) :167
7Hashiramoto M, James DE. Characterization of insulin responsive GLUT4 storage vesicles isolated from 3T32LI adipocytes [ J ]. Mol Cell Biol,2000,20( 1 ) :416
8Bryant N, Govers R, James D, et al. Regulated transport of the Glu2cose Transporter GLUT - 4 [ J ]. Nat Rev Mol Cell Biol,2002,3 (4) :267
9Baumann C,Ribon V,Kanzaki M,et al. CAP defines a second signalling pathway required for insulin stimulated glucose transport [ J ]. Nature,2000,407 (6801) :202
10Dale A, Odile P, Jason K, et al. Adipose selective targeting of the GLUT4 gene impairs insulin action in muscle andliver [ J ]. Nature, 2001,409:729
7Muhammad A. Abdul-Ghani,Ralph A. DeFronzo,Guy M. Benian.Pathogenesis of Insulin Resistance in Skeletal Muscle[J].Journal of Biomedicine and Biotechnology.2010
8Ralph A DeFronzo.Pathogenesis of type 2 diabetes mellitus[J].Medical Clinics of North America.2004(4)
9Maianu L,Keller SR,Garvey WT.Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus:implications regarding defects in vesicle trafficking[J].The Journal of Clinical Endocrinology and Metabolism,2001,86(11):5450-5456.
10Zisman A,Peroni OD,Abel ED,et al.Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance[J].Nature Medicine,2000,6(8):924-928.
