期刊文献+

探针D13S319和D13S25检测多发性骨髓瘤13q14缺失 被引量:1

原文传递
导出
摘要 多发性骨髓瘤(MM)核型异常是MM主要的预后因素之一,13q14缺失是最常见的一种染色体异常。间期荧光原位杂交(I-FISH)技术由于不受细胞分裂相影响,高纯度细胞分离的磁珠分选系统(MACS)富积了骨髓瘤细胞,二者可极大地提高MM核型异常的检出率。本研究用该技术和位于13q14的序列特异性DNA探针D13S319和D13S25,对42例初治MM患者的13q14缺失进行检测分析。
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2008年第1期89-90,共2页 Chinese Journal of Laboratory Medicine
基金 江苏省社会发展基金资助项目(BS2006071) “江苏省医学领军人才”项目资助课题 江苏省高校自然科学基础研究项目资助课题(07KJB320074)
  • 相关文献

参考文献11

  • 1Kroger N, Schilling G, Einsele it, et al. Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation. Blood, 2004,103:4056-4061.
  • 2葛峥,李建勇.13号染色体缺失与多发性骨髓瘤[J].中华血液学杂志,2003,24(4):219-221. 被引量:16
  • 3Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol, 2005,23:3412-3420.
  • 4徐卫,李建勇,潘金兰,仇海荣,沈云锋,肖冰,吴亚芳,薛永权.荧光原位杂交技术检测慢性淋巴细胞白血病p53基因的缺失[J].中国癌症杂志,2006,16(1):17-19. 被引量:4
  • 5Chang H, Li D, Zhuang L, et al. Detection of chromosome 13q deletions and IgH translocations in patients with multiple myeloma by FISH: comparison with karyotype analysis. Leuk Lymphoma, 2004,45 : 965 -969.
  • 6Pantou D, Rizou H, Tsarouha H, et al. Cytogenetic manifestations of multiple myeloma heterogeneity. Genes Chromosomes Cancer, 2005,42:44-57.
  • 7Shaughnessy J Jr, Tian E, Sawyer J, et al. Prognostic impact of cytogenetic and interphase fluorescence in situ hybridizationdefined chromosome 13 deletion in multiple myeloma: early results of total therapy Ⅱ. Br J Haematol, 2003,120:44-52.
  • 8Fiserova A, Hajek R, Holubova V, et al. Detection of 13q abnormalities in multiple myeloma using immunomagnetieally selected plasma cells. Neoplasma, 2002,49:300-306.
  • 9Shaughnessy J, Tian E, Sawyer J, et al. High incidence of chromosome 13 deletion in multiple myeloma detected by muhiprobe interphase FISH. Blood, 2000,96 : 1505-1511.
  • 10Zojer N, Konigsberg R, Aekermann J, et al. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood, 2000,95 : 1925-1930.

二级参考文献5

  • 1International Workshop on Chronic Lymphocytic Leukemia. Chronic lymphocytic leukem a: recommendations for diagnosis, staging,and response criteria [ J]. Ann Intern Med, 1989,110 ( 3 ) : 236-238.
  • 2Gozzetti A, Crupi R, Tozzuoli D. The use of fluorescence in situ hybridization (FISH) in chronic lymphocytic leukemia (CLL)[J]. Hematology,2004,9( 1 ) : 11-15.
  • 3Thornton PD, Grnszka-Westwood AM, Hamoudi R,et al. Characterisation of TP53 abnormalities in chronic lymphocytic leukaemia[J]. Hematol J,2004,5(1) : 47-54.
  • 4Stilgenbauer S, Dohner H. Molecular genetics and its clinical relevance [ J ]. Hematol Orwol Clin North Ant,2004,18 (4) :827-848.
  • 5N. Worel,H. Greinix,J. Ackermann,H. Kaufmann,E. Urbauer,P. H?cker,H. Gisslinger,K. Lechner,P. Kalhs,J. Drach. Deletion of chromosome 13q14 detected by fluorescence in situ hybridization has prognostic impact on survival after high-dose therapy in patients with multiple myeloma[J] 2001,Annals of Hematology(6):345~348

共引文献17

同被引文献3

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部