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PCR结合酶切和微流控电泳检测载脂蛋白CⅢ基因C-482T多态性 被引量：3

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摘要 载脂蛋白CⅢ（apo CⅢ）由79个氨基酸残基组成，其相对分子质量为8800，主要在肝脏中合成，小肠中也有少量表达。apo CⅢ通过抑制脂蛋白脂肪酶（LPL）、肝脂酶（HL）以及受体活性影响血浆富含甘油三酯脂蛋白（TRL）的代谢，apo CⅢ通过表达可延缓TRL如乳糜微粒（CM）和极低密度脂蛋白（VLDL）脂解的速度，从而引起高甘油三酯血症（HTG）。
作者 王惠民 俞娟 孙承龙 张志泉 褚少朋 吴翔 徐耀忠 周锦红
机构地区 南通大学附属医院检验科南通大学公共卫生学院
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2008年第1期94-96,共3页 Chinese Journal of Laboratory Medicine
基金 江苏省社会发展基金资助项目（BS2005032） 江苏省南通市社会发展基金资助项目（S2006031）
关键词 载脂蛋白CⅢ基因 电泳检测 多态性 PCR 富含甘油三酯脂蛋白 极低密度脂蛋白 高甘油三酯血症 酶切
分类号 R686 [医药卫生—骨科学]
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参考文献13

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二级参考文献29

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共引文献71

同被引文献31

  • 1毕楠,鄢盛恺,李国平,尹志农,薛红,吴刚,陈保生.冠心病患者载脂蛋白A5和载脂蛋白C3基因多态性的研究[J].中华心血管病杂志,2005,33(2):116-121. 被引量：47
  • 2陈建忠.DNA测序中的毛细管凝胶电泳技术[J].医疗设备信息,2005,20(1):42-43. 被引量：3
  • 3李国平,陈保生,薛红,曾武威,吴刚.载脂蛋白C3基因多态性-482C>T与血浆脂质的关系[J].中国动脉硬化杂志,2005,13(3):335-339. 被引量：12
  • 4俞娟,王惠民,张志泉,陈连英,周锦红,于婷.PCR-RFLP检测载脂蛋白CⅢ基因T-455C多态性方法的建立及应用[J].临床检验杂志,2007,25(4):276-279. 被引量：5
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  • 8Miller M, Rhyne J, Khatta M, et al. Prevalence of the APOC3 promoter polymorphisms T-455C and C-482T in Asian Indians[J]. Am J Cardiol, 2001,87(2) :220.
  • 9Olivieri O, Bassi A, Stranieri C, et al. Apolipoprotein C-Ⅲ, metabolic syndrome, and risk of coronary artery disease [ J ]. J Lipid Res, 2003,44 (12) : 2374.
  • 10Guettier J, Georgopoulos A, Michael Y, et al. Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-Ⅲ Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population [ J ]. J Clin Endocrinol Metab, 2005,90 ( 3 ) : 1705.

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二级引证文献2

中华检验医学杂志
2008年 第1期

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