伽玛刀在眼眶静脉性血管瘤中的应用

Gamma knife radiosurgery in venous angioma of orbit

目的研究立体定向伽玛刀(γ刀)对眼眶静脉性血管瘤的治疗作用及意义。方法对1997～2005年诊断为眼眶静脉性血管瘤的8例患者行立体定向γ刀治疗的资料进行回顾性分析。病变容积1.0～29.3mL;边缘剂量15～20Gy,平均(16.47±1.26)Gy;视神经平均受照剂量(6.13±1.88)Gy。γ刀治疗后随访18～72个月,中位随访时间为27个月。结果复查MRI显示8例病变体积全部缩小,2例体积缩小超过50%,所有患者突眼症状基本缓解,视力提高。结论立体定向γ刀对于眼眶静脉性血管瘤具有良好的治疗效果。

Objective Venous angioma of orbit is a type of vascular malformation and is diffieuh to cure only by operation. As gamma knife was used in ophthalmology, this type of disease get excellent curative effect. This investigation was to assess the results and significances of gamma knife radiosurgery in a series of 8 patients with intraorbital venous angioma. Methods Eight patients with intraorbital venous angioma underwent gamma knife radiosurgery from September 1997 to June 2005 in our hospital. The mean volume of the tumor before gamma knife radiosurgery was 7.28 ±3.53 mm3 （ranged 1.0 to 29.3 mm3 ）. The prescription peripheral dose varied between 15 and 20 Gy （mean 16.47 ± 1.26Gy） , and that for optic nerve was 6. 13 ± 1.88 Gy. The median follow-up period was 27 months（ranged from 18 to 72 months）. Results Tumor shrinkage was seen in all patients,and the shrinkage was over 50% in 2 patients. The exophthalmos of all patients got improvement and visual acuity elevated after gamma knife radiosurgery. None of patients had severe adverse effect. Conclusion Gamma knife radiosurgery provides an effective management strategy in patients with intraorbital venous angioma.