摘要
2000年首次被人们发现的Olig基因是编码碱性-螺旋-环-螺旋（basic helix-loop-helix，bHLH）转录因子的一个亚家族，它参与了运动神经元、少突胶质细胞和星形胶质细胞的分化，在中枢神经系统（CNS）髓鞘形成和脱髓鞘疾病中发挥重要作用。在不同类别的胶质瘤中，Olig基因表达不同。此外，Olig基因还与脑缺血损伤密切相关。
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2008年第1期58-60,共3页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目（30570626）
参考文献24
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同被引文献16
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1Bronchain O J, Pollet N, Ymlahi-Ouazzani Q, et al. The olig family: phylogenetic analysis and early gene expression in Xenopus tropicalis. Dev Genes Evol,2007 ,217 :485-497.
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2Gong X, Lin T, Sun Z, et al. Oligl is downregulated in oligodendrocyte progenitor cell differentiation. Neuroreport,2008, 19 : 1203-1207.
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3Lu QR, Sun T, Zhu Z,et al. Common developmental requirement for oligodendrocyte lineage gene Olig function indicates a motor neuron/oligodendrocyte hneage connection. Cell, 2002, 109 : 75- 86.
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4Xin M, Yue T, Ma Z, et al. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Oligl-null mice. J Neurosci, 2005, 25:1354 -1365.
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5Amett HA, Fancy SP, Alberta JA, et al. bHLH transcription factor Oligl is required to repair demyelinated lesions in the CNS. Science, 2004,306 : 2111-2115.
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10Lu QR, Yuk D, Alberta JA, et al. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron,2000,25:317-329.
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