白藜芦醇的合成

Synthesis of Resveratrol

以3,5-二羟基苯甲酸为原料,经保护羟基、还原、氯代后,与亚磷酸三乙酯反应生成3,5-二甲氧基苯甲基膦酸二乙酯,再与茴香醛进行Wittig-Horner反应后于吡啶盐酸盐中脱保护得到白藜芦醇。总收率约43%。

Resveratrol was prepared from 3,5-dihydroxybenzoic acid by methylation and reduction, followed by chlorination and reaction with triethyl phosphite to give diethyl （3,5-dimethoxybenzyl） phosphonate, then condensation with anisaldehyde and deprotection with pyridine hydrochloride in overall yield of about 43 %.