2006年湘雅医院鲍曼不动杆菌临床感染分布和耐药性分析

Analysis on Distribution and Resistance Profile of Infections of Acinetobacter Baumannii in Xiangya Hospital in 2006

目的了解中南大学湘雅医院临床分离的鲍曼不动杆菌临床感染分布和耐药现状。方法应用法国梅里埃VITEK2微生物鉴定和药敏系统对收集自中南大学湘雅医院2006年1-12月的临床标本进行细菌培养鉴定及药敏分析,用WHONET5分析试验结果。结果一年间共分离鲍曼不动杆菌377株,99.2%分离自住院患者,0.8%分离自门诊患者。痰标本分离率最高达82.2%,主要引起神经外科和重症监护病房患者的下呼吸道感染。该菌对亚胺培南高度敏感达80.9%,对哌拉西林/他唑巴坦敏感率为64.7%,耐药菌株在上升。结论鲍曼不动杆菌感染以外科和重症监护病房最常见,对亚胺培南敏感率最高,且耐药性有上升趋势。

Objective To determine the distribution and resistance of clinical isolates of Acinetobacter baumannii from Xiangya Hospital of Central South University. Methods The bacterial susceptibilities to 17 kinds of antimicrobial agents were determined by automatic microorganism analytical system method using biosMerieumx VlTEK 2. The results were ana- lyzed with WHONET 5 software. Results A total of 377 strains were isolated during the period of 2006, 99.2% of them isolated from inpatients, and 0.8% of them isolated from outpatients. The isolation rate of Acinetobacter baumannii was 82.2 % in sputum specimens, and majority of the isolates caused lower respiratory tract infection in older inpatients and serious wounded ones. 80.9 % of them were susceptible to imipenem, and 64.7 % of them Susceptible to piperacillin sodium/tazobactam sodium. Multi- drug resistant strains increased annually. Conclusions The antibiotic resistance rate of Acinetobacter baumannii isolates shows a tendency towards increasing.