小剂量甲硝唑合洛伐他汀调治高脂血症的临床研究

Clinical Study of a Small Dose of Lovastatin Combined With Metronidazole in Treatment of Hyperlipidemia

目的观察小剂量甲硝唑合洛伐他汀调治高脂血症的疗效与副作用,并探讨其可能的机理。方法选取高脂血症病人180例,随机分为两组,治疗组用甲硝唑合洛伐他汀联合治疗;对照组单用甲硝唑治疗。结果两组治疗效果非常显著(P<0.05),但两组间疗效比较差异无统计学意义(P>0.05)。两药合用,其副作用则明显减少(P<0.05)。结论小剂量甲硝唑合洛伐他汀调治高脂血症疗效高、副作用少、耐受性好,是调治高脂血症的理想方法。

Objective To study the efficacy and adverse effects of Iovastatin combined with metronidazole in treatment of hyperlipidemia, and to explore its possible mechanisms. Methods A total of 180 patients with hyperlipidemia were randomly assigned into the metronidazole combined with Iovastatin group or the metronidazole alone group. Results The treatment efficacy in these 2 groups was both significant （P〈 0.0.5）, while the therapeutic effect between the 2 groups was of no statistical significance （P 〉 0.0.5）. But metronidazole when used in combination with Iovastatin, the adverse effects were significantly reduced （P〈 0.0.5）. Conclusions Metronidazole combined with Iovastatin could modulate hyperlipidemia, with less adverse effects and well toleration, which is an ideal method in treatment of hyperlipidemia.