OT强阳性新兵血清抗38KD_a抗体检测的意义

Inquiry on the significance of detecting serum antibody of 38KD_a antigen in the recruits with strong positive OT

目的:调查新兵亚临床结核感染与OT试验强阳性的相关性,探讨军队结核病预防新措施。方法:采用ELISA和免疫层析法分别检测了10399名新兵中OT强阳性者血清抗38KDa抗体和抗LAM(脂阿拉伯甘露聚糖)抗体;对抗体阳性者作为期3个月随访和1年信访。结果:OT强阳性新兵血清抗LAM抗体均为阴性;无卡痕和有卡痕OT强阳性组血清抗38KDa抗体阳性分别有5例和1例,阳性比率分别为3.96%和0.56%,差异显著(P<0.05)。抗体阳性者3个月随访发现:无卡痕OT强阳性组有3例新兵出现结核体质特征或症状,其中2例1年内诊断为胸膜炎结核,1例因身体不适调离原工作岗位。结论:血清抗38KDa抗体水平与新兵结核菌亚临床感染有关。OT强阳性且38KDa抗体阳性新兵,应给于3个月预防性抗痨治疗。

Objective： To investigate the relativity between subclinical infection of tuberculosis and strong positive OT in recruits, and to discuss new prevention measures against tuberculosis. Methods：The serum antibody to 38KDaantigen and LAM in recruits with strong positive OT were detected by ELISA and immunochromatography, The recruits with antibody positive were revisited in months and in one year. Results：The serum antibody to LAM in all recruits with OT strong positive were negative. The cases of recruits with antibody positive and OT strong positive cases in the group with or without BCG vaccination trace was 5 （3.96%） and 1 （0.56%） respectively, the difference between two groups was significant（ P 〈 0.05）. 3 cases of recruits with OT strong positive and without BCG vaccination trace were found to have the physical features of tuberculosis in 3 months and 2 cases had a diagnosis of tuberculous pleurisy in one year. Conclusion ：The level of serum antibody to 38KDaantigen is associated with the subclinic infection of tuberculosis. The recruits with OT strong positive and antibody positive to 38KD antigen should be given a preventive treatment of antituberculosis.